… of VEGFR-1 has higher affinity for VEGF than VEGFR-2, and … in in vivo models, most of what
we know about VEGFR-2 … how VEGFR-2 acts as a mechanoreceptor and closely interacts …

… receptors, known as neuropilins, occur as neuropilin 1 (NRP-… well as activation of VEGFR-1
and VEGFR-2 by VEGF-A cause … as a tracer for in vivo VEGFR-2 expression monitoring and …

… On the other hand, the reduced VEGFR-2/VEGFR-1 ratio in … endothelial cells are neuropilins
(interact with VEGF, placenta … of angiogenesis, while computational models also provide a …

… and interaction with other co-receptors such as neuropilins [… identify that VEGF-A binds to
both VEGFR-1 and VEGFR-2 in … like VEGF-A does, with evidence both in vivo and vitro [55, 58…

… ), FLT4 (coding for VEGFR-3) and Neuropilin-1 and -2 (NRP1/NRP2), … vivo, this effect is also
mediated in parallel by the VEGF/VEGFR-2 interaction, whereas VEGF that bind to VEGFR-1 …

… -TK co-receptors for the VEGF isoforms, neuropilin NRP1/2. … Resistance to VEGFR-2 blockage
occurred in pancreatic … ), has been shown to be effective against VEGFR-1/2/3, PDGFR-α/β…

… we used ex vivo (Langendorff rat heart model), in vitro (H9c2 … of diversities in the computational
models adopted for the … the VEGFA binding to VEGFR-1 and VEGFR-2, 26 abrogated the …

… and the co-receptor neuropilin-1 (NRP-1) [24,32]. … targeting VEGF-A in vivo was achieved
with the murine anti-human … via signaling through VEGFR-2 (KDR) but not VEGFR-1 [158]. …

… proliferation of human umbilical vein endothelial cells in vitro via … -1 increases VEGFR-1
expression and suppresses VEGFR-2. … However, how exactly VEGF interacts with the integrin …

… kinase receptors, named neuropilin-1 (NRP-1), and neuropilin-2 (… VEGFR-1 and VEGFR-2;
amplification of the VEGF-A signal through … Initial in vitro experiments showed that aflibercept …